A case of acute generalized exanthematous pustulosis due to amoxicillin-clavulanate with multiple positivity to beta-lactam patch testing.
نویسندگان
چکیده
We present a case of acute generalized exanthematous pustolosis (AGEP) induced by amoxicillin-clavulanate. Clinical diagnosis was confirmed by symptoms presentation and histological features (Euroscar score point compatible with definite diagnosis). Patch testing performer six months later confirmed sensitization to the culprit drug and showed positivity also to other beta-lactam antibiotics (penicillin G and cephalexin). We believe that a T cell delayed response to betalactams common ring could be involved.
منابع مشابه
Acute Localized Exanthematous Pustulosis (ALEP): Review of Literature with Report of Case Caused by Amoxicillin-Clavulanic Acid
Acute localized exanthematous pustulosis (ALEP) is a localized form of acute generalized exanthematous pustulosis, characterized by acute onset of multiple nonfollicular, pinhead-sized, sterile pustules following drug administration. Antibiotics, especially β-lactams and macrolides, have been implicated in the majority of cases, although eruption after nonsteroidal antiinflammatory drugs and ma...
متن کاملProlonged course of acute generalized exanthematous pustulosis with liver involvement due to sensitization to amoxicillin and paracetamol.
© 2009 The Authors. doi: 10.2340/00015555-0616 Journal Compilation © 2009 Acta Dermato-Venereologica. ISSN 0001-5555 Sir, The EuroSCAR group recently assigned paracetamol as “a drug of common use with no significant association” with acute generalized exanthematous pustulosis (AGEP) (1). However, some rare cases of AGEP in association with paracetamol intake have been reported (2–5). We report ...
متن کاملTopical drug-induced acute generalized exanthematous pustulosis misdiagnosed as an oral drug-related eruption.
Acute generalized exanthematous pustulosis (AGEP) is characterized by acute onset of fever with a generalized erythematous pustular eruption. It seems that more than 90% of cases with AGEP are drug-induced [1]. The most frequently involved drugs are aminopenicillins, macrolides, antimycotic drugs, calcium channel blockers, carbamazepine, and paracetamol. We report a severe case of topical drug–...
متن کاملA systemic reaction to patch testing for the evaluation of acute generalized exanthematous pustulosis.
BACKGROUND Patch tests are considered safe but adverse reactions have been reported. OBSERVATIONS A case of acute generalized exanthematous pustulosis (AGEP) provoked by a patch test with acetaminophen is described. Of special interest are the negative patch test results obtained with the offending drug. The case is discussed against the background of the putative mechanisms of AGEP and the r...
متن کاملDiagnosis of nonimmediate reactions to beta-lactam antibiotics.
Nonimmediate manifestations (i.e. occurring more than 1 h after drug administration), particularly maculopapular and urticarial eruptions, are common during beta-lactam treatment. The mechanisms involved in most nonimmediate reactions seem to be heterogeneous and are not yet completely understood. However, clinical and immunohistological studies, as well as analysis of drug-specific T-cell clon...
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ورودعنوان ژورنال:
- European annals of allergy and clinical immunology
دوره 45 5 شماره
صفحات -
تاریخ انتشار 2013